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Fluorescent Dyes for Bioconjugation
CheMatech entered an agreement with Bioacts for the distribution of its unique fluorescent technologies, offers Flamma® serieswith full spectrum for labeling antibodies, proteins, peptides and other biomolecules. Biomolecules which are fluorescence labeled by Flamma® compounds can be applied to fluorescence microscope, in-vivo imaging, Immunofluorescence(IF), cell-based reporter assays, fluorescence in situ hybridization(FISH), cell tracing, receptor labeling, etc. and other analyses of cells and tissues which are fluorescence oriented.
Flamma® Fluors series - Reactive fluorescent dyes
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ApoFlamma® PS Series
ApoFlamma® PS series is for researchers and scientists who wish to decrease cost and increase efficiency in apoptosis detection. ApoFlamma® PS series is an apoptosis detection probe that binds to phosphatidylserine. Phosphatidylserine (PS) is a phospholipid component, which usually resides in the inner leaflet of the cellular membrane. When a cell is undergoing apoptosis, PS becomes exposed to the surface of the cell. We have found a unique peptide sequence that specifically recognizes PS on the cell surface. Coupled with BioActs’ superior Flamma® Fluor Fluorescent dyes, this peptide-dye complex effectively recognizes and binds to PS on cellular surfaces to accurately indicate apoptotic cells.
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The conventional way of apoptosis detection is by using Annexin V probes. However, it has been noted the in vivo performance of annexin V still needs improvements in the areas of background noise and specificity to apoptotic cells. Through phage-display method, an unique peptide sequence was recently found to have specific affinity to histone H1 on the surface of apoptotic cells and the nucleus of necrotic cells. Compared to annexin V. ApoPep-1 is much less bulky which helps rapid clearance from blood circulation and efficient tissue penetration, which makes it more ideal for in vivo experiments. ApoFlamma® H series is a novel probe composed of Apopep-1 peptide and BioActs’ superior Flamma® Fluor fluorescent dyes.
Protected macrocyles
CYCLEN derivatives
cis-Glyoxal-Cyclen
Mono-N-Benzyl-Cyclen
trans-N-Dibenyl-Cyclen
TriBOC-Cyclen
TACN derivatives
Mono-N-Benzyl-TACN
DiBOC-TACN
CYCLAM derivatives
Mono-N-Benzyl-Cyclam
Formaldehyde-Cyclam
cis-Glyoxal-Cyclam
Dioxocyclam
Oxocyclam
trans-N-Dibenzyl-Cyclam
TriBOC-Cyclam
13ane(N4) derivatives
Oxo-(13)aneN4
Mono-N-Benzyl-(13)aneN4
TriBOC-(13)aneN4
TACD derivatives
Mono-N-benzyl-TACD
DiBOC-TACD
Linear Chelating Agents
DTPA |
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